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Thursday, 16 June 2011

High-carbohydrate diet tied to cancer


Put that sandwich down, now. As if the link between carbohydrates and the muffin-top spilling over your waistband wasn't bad enough, new research indicates that a high-carbohydrate diet may also influence your cancer risk and the growth of tumours.
Scientists at Canada's British Columbia Cancer Research Centre found that mice fed on a high-protein, low-carbohydrate diet had slower tumour cell growth than those fed a typical Western diet high in carbohydrates. While the experiments were conducted with mice, the findings appear to be strong enough to be applied to humans.
"On the Western diet, half of the mice had tumours by middle age. On the low-carb diet, none of the mice had the tumours," said Dr Gerry Krystal, who authored the study along with colleague Dr Vincent Ho.
The mice used were predisposed to breast cancer, and had a life expectancy of two years. 
Published in the July issue of Cancer Research, the study found about 70 per cent of the mice on the Western diet developed cancer by the time they died, compared with 30 per cent of those on the low-carb diet.
"Only one of the mice on the Western diet reached a normal lifespan, and half of the other mice reached or exceeded the expected lifespan."
Cancer cells depend on glucose more than normal cells do, and carbohydrates in the bloodstream convert quickly to glucose. "It's possible that by simply changing our diet to a low-carb, low-fat, high protein diet, we can starve the cancer by eliminating the glucose the tumours need to grow," said Krystal. 
The "Western diet" consisted of 55 per cent carbs, 23 per cent protein, and 22 per cent fat, while the other mice ate 15 per cent carbs, 25 per cent fat and 60 per cent protein. Krystal also noted that while the two diets contained the same number of calories, mice on the high-carb diet "gained a lot of weight".
"Taken together, our findings offer a compelling preclinical illustration of the ability of a low CHO [low carbohydrate] diet in not only restricting weight gain but also cancer development and progression," the study concluded.
"I would like to see people go up to 35 per cent protein," said Krystal, who suggested that any dietary changes to lower carbohydrates would have health benefits, although he warned that diabetes sufferers should consult a doctor before altering their diet. However, a study published last year indicated that an animal-based low-carb diet was linked to an increased risk of death, while a plant-based low-carb diet was linked to decreased risk.

Saturday, 4 June 2011

10 Things to Hate About Sleep Loss

By Camille Peri
WebMD Feature

You know lack of sleep can make you grumpy and foggy. You may not know what it can do to your sex life, memory, health, looks, and even ability to lose weight. Here are 10 surprising -- and serious -- effects of sleep loss.

1. Sleepiness Causes Accidents

Sleep deprivation was a factor in some of the biggest disasters in recent history: the 1979 nuclear accident at Three Mile Island, the massive Exxon Valdez oil spill, the 1986 nuclear meltdown at Chernobyl, and others.
But sleep loss is also a big public safety hazard every day on the road. Drowsiness can slow reaction time as much as driving drunk. The National Highway Traffic Safety Administration estimates that fatigue is a cause in 100,000 auto crashes and 1,500 crash-related deaths a year in the U.S. The problem is greatest among people under 25 years old.
Studies show that sleep loss and poor-quality sleep also lead to accidents and injuries on the job. In one study, workers who complained about excessive daytime sleepiness had significantly more work accidents, particularly repeated work accidents. They also had more sick days per accident.

2. Sleep Loss Dumbs You Down

Sleep plays a critical role in thinking and learning. Lack of sleep hurts these cognitive processes in many ways. First, it impairs attention, alertness, concentration, reasoning, and problem solving. This makes it more difficult to learn efficiently.
Second, during the night, various sleep cycles play a role in “consolidating” memories in the mind. If you don’t get enough sleep, you won’t be able to remember what you learned and experienced during the day. 

3. Sleep Deprivation Can Lead to Serious Health Problems

Sleep disorders and chronic sleep loss can put you at risk for:
  • Heart disease
  • Heart attack
  • Heart failure
  • Irregular heartbeat
  • High blood pressure
  • Stroke
  • Diabetes
According to some estimates, 90% of people with insomnia -- a sleep disorder characterized by trouble falling and staying asleep -- also have another health condition.

4. Lack of Sleep Kills Sex Drive

Sleep specialists say that sleep-deprived men and women report lower libidos and less interest in sex. Depleted energy, sleepiness, and increased tension may be largely to blame.
For men with sleep apnea, a respiratory problem that interrupts sleep, there may be another factor in the sexual slump. A study published in the Journal of Clinical Endocrinology & Metabolism in 2002 suggests that many men with sleep apnea also have low testosterone levels. In the study, nearly half of the men who suffered from severe sleep apnea also secreted abnormally low levels of testosterone during the night.

5. Sleepiness Is Depressing

In a 1997 study by researchers at the University of Pennsylvania, people who slept less than five hours a night for seven nights felt stressed, angry, sad, and mentally exhausted. Over time, lack of sleep and sleep disorders can contribute to the symptoms of depression.
The most common sleep disorder, insomnia, has the strongest link to depression. In a 2007 study of 10,000 people, those with insomnia were five times as likely to develop depression as those without. In fact, insomnia is often one of the first symptoms of depression.
Insomnia and depression feed on each other. Sleep loss often aggravates the symptoms of depression, and depression can make it more difficult to fall asleep. On the positive side, treating sleep problems can help depression and its symptoms, and vice versa.

6. Lack of Sleep Ages Your Skin

Most people have experienced sallow skin and puffy eyes after a few nights of missed sleep. But it turns out that chronic sleep loss can lead to lackluster skin, fine lines, and dark circles under the eyes.  
When you don’t get enough sleep, your body releases more of the stress hormone cortisol. In excess amounts, cortisol can break down skin collagen, the protein that keeps skin smooth and elastic.
Sleep loss also causes the body to release too little human growth hormone. When we’re young, human growth hormone promotes growth. As we age, it helps increase muscle mass, thicken skin, and strengthen bones.
“It’s during deep sleep -- what we call slow-wave sleep -- that growth hormone is released,” says Phil Gehrman, PhD, CBSM, assistant professor of psychiatry and clinical director of the Behavioral Sleep Medicine program at the University of Pennsylvania in Philadelphia. “It seems to be part of normal tissue repair -- patching the wear and tear of the day.”

7. Sleepiness Makes You Forgetful

Trying to keep your memory sharp? Try getting plenty of sleep.
In 2009, American and French researchers determined that brain events called “sharp wave ripples” are responsible for consolidating memory. The ripples also transfer learned information from the hippocampus to the neocortex of the brain, where long-term memories are stored. Sharp wave ripples occur mostly during the deepest levels of sleep.

8. Losing Sleep Can Make You Gain Weight

When it comes to body weight, it may be that if you snooze, you lose. Lack of sleep seems to be related to an increase in hunger and appetite, and possibly to obesity. According to a 2004 study, people who sleep less than six hours a day were almost 30 percent more likely to become obese than those who slept seven to nine hours.
Recent research has focused on the link between sleep and the peptides that regulate appetite. “Ghrelin stimulates hunger and leptin signals satiety to the brain and suppresses appetite,” says Siebern. “Shortened sleep time is associated with decreases in leptin and elevations in ghrelin.”
Not only does sleep loss appear to stimulate appetite. It also stimulates cravings for high-fat, high-carbohydrate foods. Ongoing studies are considering whether adequate sleep should be a standard part of weight loss programs

9. Lack of Sleep May Increase Risk of Death

In the “Whitehall II Study,” British researchers looked at how sleep patterns affected the mortality of more than 10,000 British civil servants over two decades. The results, published in 2007, showed that those who had cut their sleep from seven to five hours or fewer a night nearly doubled their risk of death from all causes. In particular, lack of sleep doubled the risk of death from cardiovascular disease.

10. Sleep Loss Impairs Judgment, Especially About Sleep

Lack of sleep can affect our interpretation of events. This hurts our ability to make sound judgments because we may not assess situations accurately and act on them wisely.
Sleep-deprived people seem to be especially prone to poor judgment when it comes to assessing what lack of sleep is doing to them. In our increasingly fast-paced world, functioning on less sleep has become a kind of badge of honor. But sleep specialists say if you think you’re doing fine on less sleep, you’re probably wrong. And if you work in a profession where it’s important to be able to judge your level of functioning, this can be a big problem.
“Studies show that over time, people who are getting six hours of sleep, instead of seven or eight, begin to feel that they’ve adapted to that sleep deprivation -- they’ve gotten used to it,” Gehrman says. “But if you look at how they actually do on tests of mental alertness and performance, they continue to go downhill. So there’s a point in sleep deprivation when we lose touch with how impaired we are.



Wednesday, 1 June 2011

Rapid eye movement sleep (REM)


Rapid eye movement sleep (REM sleep) is a normal stage of sleep characterized by the random movement of the eyes. REM sleep is classified into two categories: tonic and phasic.[1] It was identified and defined by Nathaniel Kleitman and Eugene Aserinsky in the early 1950s.
Criteria for REM sleep includes rapid eye movement, but also low muscle tone and a rapid, low-voltage EEG; these features are easily discernible in apolysomnogram, the sleep study typically done for patients with suspected sleep disorders.
REM sleep in adult humans typically occupies 20–25% of total sleep, about 90–120 minutes of a night's sleep. During a normal night of sleep, humans usually experience about four or five periods of REM sleep; they are quite short at the beginning of the night and longer toward the end. Many animals and some people tend to wake, or experience a period of very light sleep, for a short time immediately after a bout of REM. The relative amount of REM sleep varies considerably with age. A newborn baby spends more than 80% of total sleep time in REM.[2] During REM, the activity of the brain's neurons are quite similar to that during waking hours; for this reason, the REM-sleep stage may be called paradoxical sleep.[3] This means there are no dominating brain waves during REM sleep.[citation needed]
REM sleep is physiologically different from the other phases of sleep, which are collectively referred to as non-REM sleep (NREM sleep). Vividly recalleddreams mostly occur during REM sleep.

Info : wikipedia.org